Abstract
The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated.
MeSH terms
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Animals
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Anura
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Protein Binding
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Pyrrolizidine Alkaloids / chemical synthesis*
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Pyrrolizidine Alkaloids / metabolism*
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Receptors, Nicotinic / metabolism*
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Torpedo
Substances
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Pyrrolizidine Alkaloids
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Receptors, Nicotinic